The placenta is not only a rich source of mesenchymal stem cells, its tissue contains many different biologically active substances. These are cytokines, hormones, vitamins, proteins with specialized functions, enzymes, trace elements. Therefore, placenta extract has found application in medicine and cosmetology as a drug with immunomodulatory, restorative and anti-inflammatory properties. Unique biochemical properties allow the use of placenta extract in dermatology, therapy, surgery, traumatology, neurology, gynecology.
It is known that placenta extract stimulates the formation of collagen, the main protein of connective tissue, which provides skin turgor. The neuroprotective action of the placenta extract allows considering this drug as promising for the treatment and rehabilitation of patients with neurological diseases, spinal cord and brain injuries. Numerous publications indicate the positive effect of placenta preparations in the case of hormonal imbalance in women, climacteric syndrome, and gestosis in pregnant women. The effectiveness of the use of placenta extract for the treatment of erosive lesions of the cervix and vagina has been shown.
The Institute of Cell Therapy has clinically proven methods of producing placenta extract and many years of successful experience in using this drug in various fields of medicine. Clinicians of the Institute of Cell Therapy have developed programs for rehabilitation and anti-age therapy using placenta extract, as well as programs for the recovery of women after childbirth. Scientists of the Institute of Cell Therapy have also developed a cream based on placenta extract that can be used by both women and men. This cosmetic contains 6% placenta extract, deeply moisturizes the skin, improves its tone and smoothes wrinkles.
In recent years, increased interest in placenta extract has been observed all over the world. Japanese scientists Yamagata Mitsuyoshi et al in 2024, published an article in the scientific journal Clinical Science describing the experience of using human placenta extract in the treatment of liver cirrhosis. These are experimental studies, but their results are extremely important for planning clinical trials. Placenta extract was administered subcutaneously to experimental animals three times a week at a dose of 3.6 ml/kg. It has been shown that the use of placenta extract has an immunotropic, anti-inflammatory and antioxidant effect, reduces liver fibrosis and the degree of early cirrhosis.
And an article recently published by Ukrainian scientists in the “Odesa Medical Journal” demonstrates the analgesic (pain-killing) properties of placenta extract. Experimental studies were conducted on the model of rheumatoid arthritis in rats. Cryopreserved mesenchymal stem cells were also characterized by comparable analgesic activity. Importantly, the placenta extract had analgesic activity both at the spinal (at the level of the spinal cord) and at the supraspinal (above the spinal cord) levels of nociception, i.e. pain perception.
Experimental and clinical research conducted in different parts of the world will facilitate wider introduction of new treatment methods using placenta extract into clinical practice.
Source:
https://pubmed.ncbi.nlm.nih.gov/38381799/,
https://journals.onmedu.od.ua/index.php/med/article/view/83/68
