Collection, processing and storage of cord blood and umbilical cord
Stem cells are the progenitors of all cells in the body. Their feature is the undifferentiated state. In case of illness, they can replace any damaged cell and become a blood, organ or tissue cell
Hematopoietic stem cells that are involved in the hematopoietic system and form the immune system, as well as mesenchymal stem cells, which differentiate into cells of the bone, connective tissue, blood vessels, and smooth muscles, are distinguished
Cord blood and umbilical cord
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Cord blood remains after cutting the umbilical cord and is an ideal source of hematopoietic stem cells for the treatment of haematologic and immune system disorders, as well as many others, including those previously incurable (leukemia and other types of cancer)
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The umbilical cord is a rich source of mesenchymal stem cells, which are already used in the treatment of heart disease, for growing new vessels, skin, repair the liver and brain
Collection of umbilical cord blood and umbilical cord
The collection is conducted by an obstetrician-gynecologist who takes delivery. This can be both physiological labor and cesarean section. The procedure for conducting the collection is regulated by the legislation of Ukraine (Order of the Ministry of Health of Ukraine No. 481 of July 10, 2014)
The procedure is safe for mother and child and takes place without any physical contact with the baby
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Conclusion of Contract
Notification by the representative of the Cryobank of the obstetrician-gynecologist about the collection of tissue (cord blood, umbilical cord)
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Collection of biological specimen
After the baby is born, the obstetrician-gynecologist places the collected biological specimen in a thermal container and recordsin the accompanying forms
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Notification of Cryobank about collection of biospecimen
A message to Cryobank about the fact of collecting biospecimen by the telephone hotline
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Delivery of biospecimen to Cryobank
Transportation of your valuable biospecimen from any region of Ukraine by a licensed courier to Kyiv
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Processing and cryopreservation
Receptionof biospecimen and preparation for cryopreservation
Cord blood and umbilical cord processing
Cryobank guarantees reliable cryopreservation and storage of biospecimen throughout the entire period of service provision
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Cord blood processing
Receiving of biospecimen, identification, registration, preparation of the necessary accompanying forms and documents for testing
Isolation of nucleated cells of umbilical cord blood and determination of their quantitative and qualitative indicators
Adding the medium for cryoconservation and placing doses of the finished product in cryovials
Testing for sterility and the presence of infectious agents and antibodies to them in accordance with the requirements of FACT
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Umbilical cord processing
Receiving of biospecimen, identification, registration, preparation of the necessary supporting forms and documents for testing
Fragmentation of the umbilical cord and addition of cryoconservation medium
Placing cord tissue fragments in cryovials
Testing for sterility and the presence of infectious agents and antibodies to them in accordance with the requirements of FACT
Cryopreservation and long-term storage
Using a programmed freezer, umbilical cord blood and/or umbilical cord tissue is cryopreserved
Frozen biospecimen is stored in Dewar vessels in liquid nitrogen at -196° С
You can get a sample of cord blood and/or umbilical cord on demand
If necessary, the Cryobank of the Institute of Cell Therapy can arrange for the safe delivery of the sample to any medical facility in Ukraine. The transportation of frozen biospecimen must be carried out in a Dewar vessel in liquid nitrogen
Call or write, and the Cryobank consultant will give comprehensive answers to all your questions..
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As standard therapy:
- Leukemias and lymphomas
- Inborm metabolism disorders
- Inborn anemias, including sickle cell anemia
- Primary immune deficiencies
- Aplastic anemias
- Radiation disease
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As FDA-approved therapy within clinical trials:
- Cerebral palsy
- Ischemic-hypoxic brain injury
- Autism and autistic specrum disorders
- Diabetes mellitus type 1 and 2
- Diabetic ulcers
- Chronic venous ulcers of the lower extremities
- Crohns’ disease
70% parents, storing cord blood, also preserve umbilical cord stem cells. This is the tissue, in which the nature put special mesenchymal stem cells, already used in the treatment of the disorders of heart, for the growing of new vessels, skin, restoration of liver and brain
Activity. It contains new and more active cells, having higher ability to segmentation and differentiation
Cleanliness. Lack of risk of infections transmission, that is not excluded even in the case of the most rigorous examination of the donor bone marrow
Compatibility. Lower risk of the graft-versus-host reaction and other immune complications, occurring often after the transplant of donor adult stem cells
Presence of both hematopoietic and mesenchymal stem cells. This expands the opportunities of stem cells application
Endothelial progenitor cells. High content of these cells may restore vessels and heart
Every of us is unique: fingerprints, form of ears, odor. But this uniqueness is not only external, our cells are also inimitable
What is immune passport?
This is a unique combination and set of protein molecules on the surface of cells, called Human Leukocyte Antigen (HLA-antigens). “Leukocyte” because HLA proteins are mostly expressed on these blood cells
Cryobank of the Institute of Cell Therapy is the only in Ukraine, that conducts expanded testing of the biological material due to FACT requirements
Hence, this is mandatory that biological material, collected at birth by the medical personnel and further passed to the Cryobank is exposed to the following tests:
1.1. Maternity blood is tested for:
- total antibodies to HIV 1 / 2
- DNA HIV1 / 2
- total antibodies to nuclear antigen of Hepatitis B virus (HbcorAg)
- Hepatitis B DNA or HbsAg
- total antibodies to Trepanema pallidum
- total antibodies to HCV
- RNA of Hepatitis C virus
- IgM antibodies to Cytomegalovirus
- Cytomegalovirus DNA
- Herpes 6 type DNA
1.2. Umbilical cord blood is tested for:
- sterility
- cell viability
1.3 Umbilical cord is tested for:
- Chlamydia trachomatis DNA
- Mycoplasma DNA
- Ureaplasma spp DNA
- Cytomegalovirus DNA
- Simple Herpes virus type ½ DNA
- Sterility
When choosing the Cryobank, be sure to ask about the list of investigations of the biological material
Cryobank of the Institute of Cell Therapy compulsorily indicates this data in the contract!