Aging is an irreversible physiological process, genetically programmed in every living organism. However, in recent years, more and more publications have appeared in authoritative scientific publications that highlight approaches to improving the quality of life of older people and preventing diseases of old age, based on the achievements of modern cell biology and genetics. The fact that the development of medical science and sanitary and vaccination culture contributes to longevity is confirmed by the fact that in 1948, when the World Health Organization was founded, the average life expectancy in the world was barely 46 years, while today it is predicted that, for example, in China by 2035 the average life expectancy will reach 81 years.
The aging processes in the human body are largely due to a decrease in the functional activity of cells, in particular stem cells. The supply of the latter throughout a person’s life also steadily decreases, so the body’s ability to regenerate weakens, wound and fracture healing processes slow down. At the molecular level, the length of chromosome telomeres decreases with age. If we look at the chromosomes of umbilical cord blood stem cells collected at birth and cells of an elderly person under optical magnification, the former will differ primarily in longer chromosome telomeres. These molecular features determine the higher ability of umbilical cord blood cells to divide and transform into other types of cells, which can be used in regenerative and anti-age medicine schemes.
In July 2025, an article by Li He and co-authors appeared in the international scientific journal Frontiers of Aging, scientifically describing the mechanisms of the anti-aging effect of stem cells. Researchers note that these mechanisms are complex, but in particular they include the restorative effect of stem cells, their ability to regulate metabolic processes, reduce inflammation, and have an immunomodulatory effect. To date, it has been proven that stem cells injected into the heart can transform into cardiomyocytes, i.e. myocardial cells, restoring its structure and function. The regenerative effect of stem cells is also associated with their ability to secrete numerous growth factors that stimulate the growth and repair of other tissues.
In anti-aging therapy, mesenchymal stem cells are most often used, as evidenced by the analysis of 11 clinical studies conducted by the authors of the above-mentioned publication. The proven clinical efficacy of the drug of the bone marrow allogeneic mesenchymal stem cells in the treatment of senile weakness in the elderly is reported. There are more and more scientific publications that demonstrate the effectiveness of stem cells in treating unwanted skin changes caused by aging, as well as in treating baldness and eliminating other cosmetic defects.
The article is based on the data of the Association of Cryobanks and https://www.frontiersin.org/journals/aging/articles/10.3389/fragi.2025.1638168/full
