The patient has been living more than 50 years after the hematopoietic stem cells transplant

Nancy King McLean in 1963 was performed a bone marrow transplant, and to date, this woman is considered the world’s most long-living recipient of hemopoietic stem cells. During all these 50 years, Nancy has been treated by the same hematologist, for whom she once had been the first patient to undergo a bone marrow transplant

The life of Nancy resembles the section of the medical textbook. In 1960, little Nancy and her parents attended Disneyland, where she showed her mother a pillow with blood – her gums were bleeding. The dentist directed the child to the Mayo Clinic (USA), where she was treated by all the methods known at that time. In total she had 98 blood transfusions. Nancy had to go through numerous painful bone marrow biopsies, hormonal therapy that negatively affected the child’s growth. Several times doctors doubted whether a small patient would survive the night

But once Dr. Kyle, who treated Nancy, noticed her twin sister Bonniein the clinic, and this dramatically changed the further development of events. Doctors suggested Nancy a hematopoietic stem cells transplant from a bone marrow of her twin sister

Bone marrow transplantation in the 60’s of the 20th century was only started and performed only between identical twins. In 1963, a young doctor, Robert Kyle, who had just a short training at Donald Thomas, a founder of hematologic transplantology, performed his first transplantation of hematopoietic stem cells to a child

In those days, no tests were performed to determine the tissue compatibility, and both sisters had a piece of tissue from one another transplanted to their hands to make sure there would be no rejection

After bone marrow transplantation, Nancy spent 6 weeks in isolation, and her illness and bleeding ceased in June 1963. The child no longer got sick and returned to normal life

In the future, Nancy became the mother of two of her own children and grandmother of two grandchildren. She worked as a teacher at elementary school and took care of the program for children with autism

In her life, Nancy is the most grateful to Dr. Kyle and her sister, who shared her bone marrow with her

With each passing year, Nancy is becoming more and more known as the world’s longest survivor after hematopoietic stem cell transplantation. The woman is looking forward to new grandchildren, new travels and takes time to enjoy her coffee

Source: https://www.bmtinfonet.org/story/longest-living-transplant-survivor-nancys-story?fbclid=IwAR14f40vIHsy1LCJz3ZdbHZnEq3zV_SQFzkNBdjkbS4VxDe5fyG8iRDP_Lg

To date, bone marrow transplantation has become a commonly used method of treating a wide range of blood diseases, primary immunodeficiencies, some forms of cancer etc. Given the shortage of compatible bone marrow donors for needy patients, other sources of hematopoietic stem cells, primarily umbilical cord blood, are actively used throughout the world. Storage of umbilical cord blood at birth is equivalent to biological insurance, because the frozen stem cells that it contains, even after many years, can be used for treatment. The first ISO accredited cryobank of the Institute of Cell Therapy (since 2003) in Ukraine, provides services for personal storage of the umbilical cord blood, placenta, umbilical cord in accordance with international protocols